Synthesis, characterization and antioxidant properties of some metal(II) complexes of mixed drugs-vitamin Bx and aspirin

Abstract

Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of mixed drugs, Vitamin Bx and Aspirin were synthesized and characterized by infrared and electronic (solid reflectance) spectroscopies, room temperature magnetic moments, percentage metal, melting points, solubility and conductance measurements. The conductance measurement in DMSO indicated that all the metal(II)complexes were covalent and percentage metal analysis corroborated the formula mass as [M(HL)(HL1)X], where X = Cl2/SO4. Infrared spectra data confirmed that coordination was via the un-deprotonated carboxylate oxygen atoms in the Vitamin Bx, while Aspirin coordinated through its carbonyl oxygen atoms of the carboxylic acid and acetyl groups. In addition, the electronic spectra and room temperature magnetic moment data indicated that Fe(II) and Co(II) complexes were paramagnetic and the Zn(II) complex was diamagnetic.These complexes assumed an octahedral geometry. Fascinatingly, the Ni(II), Mn(II) and Cu(II) complexes were shown by the room temperature magnetic moment to be probably dimeric, and the latter two complexes exhibited antiferromagnetism. Furthermore, antioxidant studies on the complexes revealed that Ni(II) and Cu(II) complexes had the best activity of 89.87 and 87.73 percent inhibition respectively, which were higher than, and comparable with that of the standard, ascorbic acid, with an activity of 87.66 percent inhibition, proving them as potential anti-cancer agents in-vitro.