Synthesis, spectroscopic characterization and antioxidant properties of some metal (II) complexes of mixed drugs vitamin Bx and paracetamol

Abstract

Some metal(II) complexes of mixed drugs, Vitamin Bx (p-aminobenzoic acid) and Paracetamol(N-acetyl-p-aminophenol), were synthesized and characterized by solubility, percentage metal, melting points, room temperature magnetic moments, conductivity, infrared and electronic spectra measurements(M = Mn, Fe, Co, Ni, Cu and Zn). Infrared data showed that the Vitamin Bx coordinated to the metal through the un-deprotonated carboxylate oxygen atoms while the Paracetamol coordinated through its carbonyl oxygen and the un-deprotonated phenolic oxygen atoms respectively. The percentage metal analysis, electronic and infrared spectra corroborated octahedral geometry. Furthermore, the room temperature magnetic moments indicated that the Mn(II) and Co(II) complexes were dimeric, the Fe(II) complex exhibited spin-cross over and the remaining metal complexes were mononuclear. The antioxidant studies on the metal complexes showed that the Co(II) and Zn(II) complexes had the best antioxidant activity of about 98 % inhibition, which was higher than that of the standard, ascorbic acid (~88%), proving their potentials as an agents which can reduce the risk for lingering diseases such as cancer and heart disease.