The effect of ginger (Zingiber officinale) feed on cardiac biomarkers in medium-dose isoproterenol-induced myocardial toxicity

Abstract

Traditional medicines have been widely used to prevent and treat diseases for thousands of years. This study was designed to evaluate the effect of ginger feed on cardiac biomarkers in isoproterenol (ISO)-induced myocardial toxicity. Thirty male Wistar rats were grouped into six groups of five: Control; ISO-induced toxicity; ginger fed; ginger fed before; ginger fed+ ISO simultaneously and ginger fed after. Freshly prepared solution of ISO was injected through the intraperitoneal route at a dosage of 20 mg/kg, while the control received distilled water. Blood was collected via cardiac puncture after two weeks of administration, the serum was used to evaluate biomarkers. The CK-MB and CK of ginger-fed groups were significantly lower compared to ISO group- 8.2±0.5 U/L and 39.36±5.28 U/L respectively, P <0.05. The CK-MB and CK levels of all ginger-fed groups showed no significant difference compared to the control- 2.2±0.3 U/L and 17. 07±3.4.90 U/L, respectively p>0.05, except ginger fed after group where they were significantly higher compared to the control. The mean value of LDH in all ginger-fed groups was lower than the ISO group (67.17±0.88 U/L; p<0.05), but significantly higher (p<0.05) than the control (26.45±2.52 U/L). The mean value of ALT in all ginger fed groups was lower than the ISO group (83.11±4.88U/L; p≤0.05). Ginger feed hindered toxic effects of isoproterenol.