ir.bowen.edu.ng:8181/jspui/handle/123456789/525 These are articles published in journals by academic staff 2026-04-22T00:08:26Z ir.bowen.edu.ng:8181/jspui/handle/123456789/1445 Title: Hepatoprotective Effect of Turmeric on the Structural Intergrity of Liver of Pubertal Rabbits Exposed to Acute Ultraviolet Radiation Authors: Olatunji, F.; Emmanuel, T. Abstract: Background:One of the non-ionizing radiationsin electromagnetic spectrum is ultraviolet (UV) radiation. Studies haveshown that UV radiation causes the generation of reactive oxygen species and subsequent radical formation as wel as direct damage to cell macromolecule.This study was undertaken to assess the hepatoprotective effect of turmeric on rabbits acutely exposed to ultraviolet radiation. , Methods: Forty rabbits between the ages of 18-20 weeks were weight baanced into five groups, and randomy allocated to five (5) treatments: A, B, C, D, E. Group A (ttr): fed organicfeed without turmeric and not radiated, Group B (ttR): fed organic feed withoutturmeric inclusion before they were radiated. Group C (TTr): fed diet supplemented with 2% turmeric as its constituent but not radiated. Group D (TTR): fed organic feed supplemented with 2% turmeric before they were radiated. Group E (ttr) is the control: fed commercial feed along with forage throughout the experiment and not radiated. The irradiation was done for 10 minutes period for ten consecutive days. The liver of the 40rabbits were harvested and the histology of the liver section was done.Results: The histological studies revealed that the groups radiated have structura differences from the control. Liver section in Group B shows thatthere washepatic necrosis and degeneration of cels. There was also a dense portal infiltration with lobular extension, confirming the damaging effect of UV radiation. The liver damage was mild in Group D, indicating the hepatoprotective properties of turmeric. The histology of rabbit in Group A revealed ova cells of hepatocyte, which are progenitor cel that are invoved in the regeneration process. Rabbits in Group C as well as the control Group E, showed normal histological appearance. Conclusion: It was concuded that UV radiation has detrimental effect on the liver and organic turmeric has hepatoprotective properties. Key Words: liver histology, turmeric, UV radiation. 2019-01-01T00:00:00Z ir.bowen.edu.ng:8181/jspui/handle/123456789/1365 Title: Effect of sleep deprivation on hemorheological parameters in alloxan-induced diabetic rats Authors: Okomafe, N. E.; Oluranti, O. I.; Fasanmade, A. A. Abstract: Diabetes mellitus with abnormal glucose concentration is associated with changes in hemorheological properties, endothelial function, and platelets hyperactivity. Disturbances may significantly be responsible for diabetes-related vascular complications. People with diabetes are also more likely to have sleep problem/poor sleep. This study therefore investigated the hemorheologic effect of sleep deprivation on alloxan induced diabetic rats. Sixteen healthy male Wistar rats were used for the study randomly divided into non diabetic non sleep deprived, diabetic non sleep deprived, non diabetic sleep deprived and diabetic sleep deprived groups with four animals each. The animals were paradoxically sleep deprived for fourteen days with a sleep deprivation chamber. The result revealed an increase in whole blood viscosity, hematocrit, fibrinogen concentration and relative plasma viscosity in diabetic rats. However, these blood rheological properties decline in sleep deprived diabetic rats. This suggests that diabetes increase hemorheological indices which could lead to vascular complications; while sleep deprivation in normal and diabetic state reduces the hemorheological indices. It is therefore possible that paradoxical sleep deprivation did not synergistically with diabetic condition to alter blood rheological properties but otherwise. 2017-01-01T00:00:00Z ir.bowen.edu.ng:8181/jspui/handle/123456789/1346 Title: Aripiprazole ameliorates scopolamine-induced amnesia in mice Authors: Adedayo, L.; Offor, G.; Jolayemi, O.; Ojo, G.; Bamidele, O.; Ojo, A.; Emmanuel, T.; Aitokhuehi, N.; Onasanwo, S.; Ayoka, A. Abstract: Aripiprazole, a known third generation anti-psychotic drug. The drug has shown to have lesser side effects on extrapyramidal system and enhance memory when compared with the first-generation anti-psychotic drugs. However, studies on the impact of aripiprazole on scopolamine-induced memory impairment in mice have been poorly reported. This study was designed to investigate the impact of aripiprazole on scopolamine-induced amnesia in mice. (36) mice weighing between 20-23g were randomly divided into six groups. Group 1 was given 10 ml/kg distilledwater. Group 2 received 3 mg/kg scopolamine alone. Group 3 was given 1 mg/kg donepezil. Group 4 received 0.5 water. Group 2 received 3 mg/kg scopolamine alone. Group 3 was given 1 mg/kg donepezil. Group 4 received 0.5mg/kg aripiprazole. Group 5 was given 0.3 mg/kg aripiprazole. Group 6 received 0.1mg/kg aripiprazole. Thirty minutes after administration of either aripiprazole or donepezil, scopolamine (3 mg/kg) was administered, intraperitoneally. The administration was for 7days, during which their memory was assessed using Morris water maze and Y-maze models. The results showed that the anti-amnesic effect of aripiprazole appeared to be dosedependent; the animals administered with 0.5 mg/kg aripiprazole showed the greatest improved memory performance against scopolamine-induced amnesia. The hippocampal and prefrontal cortex tissues displayed anti-amnesic potential of aripiprazole. Aripiprazole seems to improved memory performance against scopolamine-induced memory impairment in mice. 2021-01-01T00:00:00Z ir.bowen.edu.ng:8181/jspui/handle/123456789/1344 Title: Methanol extract of Cola nitida ameliorates inflammation and nociception in experimental animals Authors: Adedayo, L.; Ojo, A.; Awobajo, F.; Adeboye, B.; Adebisi, J.; Bankole, T.; Ayilara, G.; Bamidele, O.; Aitokhuehi, N.; Onasanwo, S. Abstract: Methanol extract of Cola nitida (MECN) was evaluated for its anti-inflammatory and analgesic activities using rats and mice. Inflammatory activity of MECN was assessed by carrageenan-induced paw oedema while analgesic activity was evaluated by acetic acid –induced writhing and formalin paw lick test. Histological analyses of the paws were also carried out. There was evaluation of the mechanism(s) of action of MECN using naloxone, a blocker of opioid receptors; atropine, blocker of muscarinic receptors; and propranolol, blocker of beta adrenergic receptors. Findings from the study revealed that MECN has both anti-inflammatory and analgesic properties. These properties were found to be dose dependent with 200 mg/kg of MECN discovered to be the most potent dose. 200 mg/kg was able to cause statistically significant reduction in paw size (p < 0.001) when compared with the carrageenan group. Histological analysis revealed that rats treated with 200 mg/kg of MECN showed no inflammatory cells in the left paw compared to other groups treated with carrageenan. In the formalin test, the number of paw licking was significantly reduced by MECN at 50 mg/kg, 100 mg/kg and 200 mg/kg in both neurogenic and inflammatory pain responses (p < 0.001) even as 200 mg/kg showed the highest percentage inhibition of 98.17% while 100 mg/kg of aspirin showed percentage inhibition of 93.66%. In acetic acid-induced writhing test, 50 mg/kg, 100 mg/kg and 200 mg/kg of MECN produced significant inhibition of writhes when compared with control as highest inhibition is observed in mice that received 200 mg/kg which is similar to aspirin. Administration of propranolol and naloxone was unable to reverse the analgesic function of MECN. However, atropine administration blocked the analgesic function of MECN. This shows that MECN exhibits its analgesic property through cholinergic pathway and not opioid and adrenergic pathways. Phytochemical screening revealed that MECN contains flavonoids, steroids, saponins, tannins, anthraquinones, terpenoids, and alkanoids. These phytochemical contents may thus be responsible for its analgesic and anti-inflammatory properties. 2019-01-01T00:00:00Z