Biopsy proven acute interstitial nephritis secondary to non-steroidal anti inflammatory drugs abuse in a sixty two year old man

Abstract

Acute interstitial nephritis (AIN) can be caused by non-steroidal anti inflammatory drugs (NSAIDs) particularly in prolonged therapy and large doses. We present the management and reviewed the literature. Sixty-two year old man with, vomiting and hiccups of one week after seven weeks of daily Diclofenac sodium 100mg and Meloxicam 15 mg, for body pains. Results: He had asterixis. Laboratories showed pyuria, haematuria, anemia (28%), creatinine (714 µmol/L) and potassium (6.9 mmol/L). Histology showed acute interstitial nephritis. He had cardio-protective treatment and haemodialysis, with kidney function restoration. Conclusion: NSAIDs should be taken in low, single doses and, for short period to avoid AIN. Haemodialysis is beneficial in restoring kidney function.